Formulation and Preparation of Felodipine Nanoemulsions

نویسندگان

  • POLURI KOTESWARI
  • SISTLA RAMA KRISHNA
  • VEERAREDDY PRABHAKAR REDDY
  • LAKSHMI M NARASU
چکیده

The objective of present work was development of felodipine nano emulsion formulations using sesame oil as sole lipid phase by high pressure homogenization technique. A combination of non-ionic surfactants was used based on HLB (Hydrophilic lipophilic balance) values. The resultant nano emulsions were characterized for particle size, zeta potential. The particle size for the optimized nano emulsions was 162.7±8.1 and zeta potential was -37.5±5.2. Percentage drug content was found to be 79.56±1.43%. Centrifugation and freeze – thaw cycling showed no signs of creaming.

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تاریخ انتشار 2011